AguiloLab: Epigenetics and RNA modifications

Epigenetic and RNA-based gene regulation of cell fate and breast cancer.

Our main interest is to decipher novel epigenetic and epitranscriptomic mechanisms affecting global gene expression and their implication in cell fate and cancer initiation and progression with a focus on breast cancer. We aim to elucidate the function of RNA modification, specifically adenosine methylation, and their crosstalk with other epigenetic marks, using stem cells and breast cancer cells, as physiological and pathological models.